Directing T-cell immune responses for cancer vaccination and immunotherapy. Peter Lawrence Smith * Katarzyna Piadel and Angus George Dalgleish
Abstract: Cancer vaccination and Immunotherapy has revolutionised the treatment of cancer, a result of decades of research into the immune system in health and disease. However, despite recent breakthroughs in treating otherwise terminal cancer only a minority of patients respond to cancer immunotherapy and some cancers are largely refractive to immunotherapy treatment. This is due to numerous issues intrinsic to the tumour, its microenvironment or to the immune system. CD4+ and CD8+ αβ T-cells have emerged as the primary effector cells of the anti-tumour immune response but their function in cancer patients is often compromised. This review details the mechanisms by which T-cell responses are hindered in the setting of cancer and refractive to immunotherapy, and details many of the approaches under investigation to direct T-cell function and improve the efficacy of cancer vaccination and immunotherapy.
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The reviews for this were very positive and included the following comments:
“The review article is very well written, well-organised and provides all promising directions that scientists currently employ to improve T-cell efficacy for cancer immunotherapy” – Reviewer 1
“Overall the article is well written and interesting. The authors have thoroughly looked up the literature and cited the most recent literature. The authors covered all possible updates related to the topic. I really appreciate the efforts made by the authors” – Reviewer 2
“The manuscript is of very good quality and urgent importance and is very well written and edited in order to meet the standard for the articles published in Vaccines. The article is concluded with a rich collection of 238 references. Additionally, all 5 Tables are very informative and with concise important data with literature references. All 3 Figures are beautifully designed with excellent logistical sequences (Figure 3 with 5 stages!) for which authors should be congratulated”. – Reviewer 3